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ORE Part 1

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13.1 Oral Medicine – Systemic Diseases and Oral Manifestations

Drug-Induced Conditions

  • Drugs, particularly antidepressants and antihistamines, are the most common cause of xerostomia. Dentists should be aware of this when treating patients with dry mouth. [Q3639]
  • True xerostomia is often considered a side effect of medication. Identifying the cause is crucial for appropriate management. [Q3960]
  • In severe xerostomia, saliva secretion can drop significantly below 1 ml/minute. This reduction severely impacts oral health and comfort. [Q4108]
  • Yes, in true xerostomia, salivary flow can drop to around 0.1 ml/minute. Such low flow rates can lead to significant oral health issues. [Q4131]
  • Yes, irradiation, Sjogren’s syndrome, and dehydration can all cause true xerostomia. Managing these conditions is essential for improving salivary flow. [Q4190]
  • Mouth breathing can lead to false xerostomia, exacerbating conditions like candidiasis or lichen planus. This should be considered in the differential diagnosis of dry mouth. [Q4390]

General Pathophysiology

  • Attrition refers to the normal wear of teeth resulting from tooth-to-tooth contact over time. It’s a common finding in aging populations. [Q165]
  • Central haemangioma is an expansile lesion of the jaw bone. Such lesions require careful monitoring and management. [Q799]
  • Oral mucosal pigmentation is commonly seen in ethnic groups. It’s a benign condition often requiring no treatment. [Q915]
  • Giant cell lesions in the jaws are characterized by the presence of multinucleated giant cells. These lesions can be aggressive and need appropriate management. [Q3075]
  • Yes, an aneurysmal bone cyst can cause bone expansion and root resorption without teeth displacement. Early detection is important for management. [Q3265]
  • Erythromelalgia is a condition characterized by redness, heat, and pain in the extremities. It’s a rare disorder that requires specialist care. [Q3298]
  • A CT scan provides detailed images and is suitable for assessing mandibular buccolingual expansion. This imaging technique is essential for accurate diagnosis. [Q3307]
  • Erythema multiforme often affects the vermilion border of the lips. Recognizing this pattern helps in early diagnosis and treatment. [Q3688]
  • Exocrine glands secrete substances through ducts to the surface of the body. They play a vital role in various physiological processes. [Q3699]
  • In hypomineralization, the enamel thickness stays normal but is less mineralized. This condition affects the enamel’s durability. [Q4085]
  • Yes, the leeway space is 2.5 mm in the mandible and 1.5 mm in the maxilla. This space is important in orthodontic treatment planning. [Q4232]
  • Yes, the leeway space is the difference between the widths of primary and permanent canines and molars. This measurement is crucial for managing space in pediatric patients. [Q4233]
  • Yes, different forceps are required for left and right lower molars to fit their buccal peaks properly. Proper instrumentation is essential for efficient extractions. [Q4234]
  • The primary function of the dental pulp is to produce dentin. This is vital for tooth health and response to injury. [Q4269]
  • A dentigerous cyst typically encapsulates the crown of an unerupted tooth. Early diagnosis can prevent complications. [Q4287]
  • A good blood supply is essential for overall tissue health in the oral cavity. This is crucial for healing and resistance to infection. [Q4292]
  • Perikymata are horizontal ridges commonly seen in recently erupted teeth. They are normal anatomical features. [Q4585]
  • Perikymata are horizontal ridges, not vertical. Recognizing these ridges helps in identifying normal tooth anatomy. [Q4586]
  • Peripheral giant cell granulomas are common in adults. These lesions often require surgical removal. [Q4590]
  • The presence of osteoclasts helps distinguish peripheral giant cell granulomas from pyogenic granulomas. Accurate diagnosis is essential for proper treatment. [Q4591]
  • 1.0 ppm is the recommended quantity of fluoridation in water for dental health. This helps in preventing tooth decay. [Q4689]
  • Extraction therapy is often the most appropriate treatment for significant crowding in Class II malocclusion. Proper planning ensures optimal outcomes. [Q4690]
  • A crown is typically recommended for extensive decay involving multiple cusps in a posterior tooth. This provides durability and protection for the tooth. [Q4692]
  • Local anesthetics block nerve membrane permeability to sodium ions, preventing pain transmission. This is fundamental to achieving effective anesthesia. [Q4698]
  • A stained fissure often indicates staining from food or drink, not necessarily caries. Proper assessment prevents unnecessary treatment. [Q4828]
  • A stainless steel plate is contraindicated in the treatment of papillary hyperplasia. Alternative materials should be used. [Q4829]
  • A tear in the gingiva or alveolar mucosa suggests a traumatic injury. Prompt evaluation and treatment are necessary. [Q4881]
  • The antecubital fossa is preferred for IV sedation due to easier vein access. This ensures safer and more effective sedation. [Q4925]
  • Melanin concentration determines the pigmentation of the skin. Understanding this helps in diagnosing pigmentation disorders. [Q6010]
  • Pancreatic cancer has the lowest 5-year survival rate. Early detection is crucial for improving outcomes. [Q6019]
  • Acute apical periodontitis affects a single tooth, making it easier for the patient to localize the pain. Accurate diagnosis aids in effective treatment. [Q6099]

Genetic and Developmental Disorders

  • Café au lait spots are characteristic of Recklinghausen’s disease, also known as neurofibromatosis. These spots are key diagnostic markers. [Q134]
  • Limited excision surgery is preferred for large lesions of fibrous dysplasia to address cosmetic considerations. This minimizes deformities and functional issues. [Q145]
  • All listed features are characteristic of Plummer-Vinson syndrome. This condition requires comprehensive management. [Q616]
  • Odontogenic cysts do not develop from epithelium trapped after sutures. Recognizing the origin helps in accurate diagnosis. [Q639]
  • Kawasaki disease presents with symptoms like desquamation and fever. Prompt diagnosis and treatment are essential. [Q3041]
  • Approximately 0.5% of maxillary second permanent molars have a fourth mesiobuccal root. This anatomical variation should be noted during treatment. [Q3073]
  • Hypodontia is the condition involving scanty hair and missing teeth. Recognizing this helps in managing associated dental issues. [Q3100]
  • Marfan Syndrome is characterized by tall stature, wide arm span, arachnodactyly (spider-like fingers), visual impairment, and lax ligaments. Proper management involves a multidisciplinary approach. [Q3109]
  • Pregnancy epulis is indeed a variant of pyogenic granuloma that arises during pregnancy. Management often involves monitoring and possible excision. [Q3115]
  • Ehlers-Danlos Syndrome is a connective tissue disorder that can have various manifestations in the mouth. Awareness of this condition aids in comprehensive care. [Q3653]
  • Gardner’s syndrome is commonly associated with multiple pulp stones. Early detection is crucial for managing systemic implications. [Q3804]
  • Hypocalcified amelogenesis imperfecta is characterized by normal enamel matrix thickness but weak, chalky, and opaque enamel. Treatment focuses on protecting the affected teeth. [Q3973]
  • Hypoplastic amelogenesis imperfecta features a normal matrix with a chalky appearance. Early diagnosis helps in planning appropriate restorative care. [Q3979]
  • Hypoplastic amelogenesis imperfecta can be X-linked, with females often more affected. Genetic counseling may be necessary for affected families. [Q3980]
  • Hypoplastic nails are typically of no oral significance. This helps focus treatment on more relevant oral manifestations. [Q3982]
  • Dentinogenesis imperfecta is characterized by bulbous crowns. Recognition of this condition is important for managing dental fragility. [Q4028]
  • Yes, a lateral cleft lip occurs due to the failure of fusion between the maxillary and nasal processes. Early surgical intervention can improve outcomes. [Q4228]
  • Maffucci syndrome is characterized by multiple enchondromas and soft tissue hemangiomas. Early diagnosis can guide appropriate management. [Q4290]
  • Multiple keratocysts are a common feature of Gorlin-Goltz syndrome. Regular monitoring is necessary to manage this condition. [Q4396]
  • Gardner’s syndrome can present with impacted teeth, supernumerary teeth, missing teeth, and abnormal root formation. Comprehensive care is essential for these patients. [Q4487]
  • Papilloma-Lefevre syndrome can be associated with Palmer-plantar keratosis. Early recognition aids in managing the extensive manifestations of this syndrome. [Q4514]
  • Ectodermal dysplasia can lead to sparse hair and missing teeth. Multidisciplinary care is often required for optimal management. [Q4538]
  • Xeroderma pigmentosum is associated with a high risk of pigmentation and skin cancer. Vigilant monitoring and protection from UV light are essential. [Q4539]
  • Frontal bossing is a typical feature of cleidocranial dysplasia. Recognizing this feature aids in the diagnosis and management of the condition. [Q4720]
  • Regional odontoplasia mainly affects any teeth in a localized region. This condition requires careful management to preserve oral function. [Q4732]
  • Both retrognathic mandible and cleft palate are features of Pierre Robin syndrome. Early intervention can improve functional outcomes. [Q4750]

Hematological Disorders

  • The blood analysis suggests myelogenous leukemia due to high WBC count and predominance of neutrophils. Prompt diagnosis and treatment are crucial. [Q53]
  • Leukemia can present with splenomegaly and intra-oral lesions. Early detection and comprehensive care are essential for managing this condition. [Q4559]

Immunological and Infectious Diseases

  • HIV infection often presents initially with a reduction in white cell count, indicating early immune system compromise. This can help in the early diagnosis and management of the disease. [Q0039]
  • Immune deficiency is commonly linked with an elevated incidence of Epstein-Barr virus, reflecting the compromised immune system’s inability to control latent infections. [Q0638]
  • Palpating the lymph nodes during an intraoral examination is crucial for identifying potential infections or malignancies in the head and neck region. This practice ensures comprehensive patient assessment. [Q0697]
  • HBs Ag antigens do not carry a risk of infection by themselves; their presence indicates that the hepatitis B virus is active and the patient is infectious. [Q0793]
  • In syphilis, spirochetes disseminate within 24 hours of infection, highlighting the rapid progression and need for early intervention. Timely diagnosis and treatment are essential to prevent systemic spread. [Q0964]
  • All statements about syphilis, including its transmission, symptoms, and stages, are true and underline the importance of comprehensive understanding for effective management. [Q0965]
  • A chancre typically appears about 3 weeks after syphilis infection, serving as an important diagnostic sign for early disease identification. Awareness of this timeframe aids in timely clinical intervention. [Q3040]
  • White patches, such as mucous patches, appearing in the mouth during the secondary stage of syphilis are characteristic lesions that aid in clinical diagnosis. Recognizing these symptoms is vital for accurate disease staging. [Q3094]
  • A rising titre of specific antibodies usually indicates an active viral infection, reflecting the body’s ongoing immune response. This information is critical for monitoring disease activity. [Q3123]
  • Sjogren’s syndrome often presents with dry eyes and mouth alongside positive antinuclear antibodies, helping distinguish it from other autoimmune disorders. This syndrome requires targeted management strategies. [Q3137]
  • Acute Necrotizing Ulcerative Gingivitis (ANUG) can affect immunodeficient individuals, emphasizing the need for vigilant oral hygiene and timely treatment in these patients. [Q3159]
  • ANUG is more prevalent among adolescents, particularly those with poor oral hygiene and high stress levels, underscoring the importance of preventive care and education in this age group. [Q3160]
  • Amalgam lichenoid reaction is a Type IV hypersensitivity reaction, reflecting a delayed immune response to dental materials. Recognizing this helps in appropriate management and material selection. [Q3222]
  • Anaerobic bacteria produce sulfur compounds that cause foul odor in the mouth, highlighting the importance of managing oral hygiene and bacterial balance. [Q3249]
  • Tuberculosis presents with chronic cough, hemoptysis, night sweats, and weight loss, which are key clinical features aiding in diagnosis and management of the disease. [Q3484]
  • Dry eyes and mouth are primary symptoms of Sjogren’s syndrome, necessitating a thorough examination for accurate diagnosis and management. [Q3640]
  • Elie Metchnikoff described phagocytosis, a fundamental immune process crucial for understanding the body’s defense mechanisms against infections. [Q3661]
  • Amalgam lichenoid reactions are type IV hypersensitivity reactions, highlighting the need for careful material selection and patient monitoring in dental practice. [Q3970]
  • Patients with Sjogren’s syndrome should avoid excessive sweets and citrus fruits to prevent dental erosion and caries, ensuring better oral health management. [Q4110]
  • Lymphoma is a potential complication of primary Sjogren’s syndrome, stressing the importance of regular monitoring for early detection and intervention. [Q4284]
  • Sjogren’s syndrome is more common in females, which should be considered in differential diagnosis and patient management strategies. [Q4294]
  • Mucosal diseases can frequently lead to true xerostomia, emphasizing the need for comprehensive evaluation and management of underlying conditions. [Q4392]
  • Notched incisors, known as Hutchinson’s teeth, are indicative of congenital syphilis, aiding in the diagnosis of this congenital infection. [Q4454]
  • Behcet’s syndrome is characterized by oral and genital ulcerations and can include eye problems, which are critical signs for diagnosis and management. [Q4535]
  • Pilocarpine can be used in severe cases of Sjogren’s syndrome to stimulate saliva production, providing significant symptomatic relief. [Q4617]
  • Primary Sjogren’s syndrome affects salivary and lacrimal glands and is often associated with rheumatoid arthritis, necessitating a multidisciplinary approach to treatment. [Q4668]
  • Multinucleated giant cells are a typical histological feature of herpetic lesions, aiding in the accurate diagnosis of herpes infections. [Q4681]
  • Raynaud’s syndrome is associated with both Sjogren’s syndrome and systemic sclerosis, necessitating comprehensive evaluation and management of these autoimmune conditions. [Q4718]
  • Sarcoidosis is most commonly observed between the ages of 20 to 40 years, highlighting the need for vigilance in this age group for early diagnosis and management. [Q4772]
  • Sjogren’s syndrome is an autoimmune disorder, requiring targeted therapeutic approaches to manage symptoms and prevent complications. [Q4804]
  • Sjogren’s syndrome is the most common single medical disorder causing xerostomia, making it a critical condition to identify and manage in patients presenting with dry mouth. [Q4805]
  • Steroid treatments, such as mouthwash, pellets (Orabase), and coralline (hydrocortisone), are effective in managing recurrent aphthous stomatitis (RAS). [Q4834]
  • Stress is a known trigger for erythema multiforme, highlighting the importance of stress management in susceptible individuals. [Q4838]
  • Hodgkin’s lymphoma is generally more benign compared to other lymphomas, making its identification important for prognosis and treatment planning. [Q5972]
  • Secondary Sjogren’s syndrome is associated with rheumatoid arthritis, necessitating a collaborative approach to manage both conditions effectively. [Q6045]
  • Schirmer’s test is used to measure tear production and diagnose xerophthalmia in patients with Sjogren’s syndrome, aiding in early and accurate diagnosis. [Q6060]

Infectious Diseases and Immunological Responses

  • Taking a radiograph and testing the vitality of the teeth is essential to determine the cause of swelling and appropriate treatment in a teenager with facial swelling. [Q0267]
  • Cavernous sinus thrombosis is a serious and potentially life-threatening complication of a maxillary canine abscess, highlighting the need for prompt diagnosis and treatment. [Q0360]
  • Pericoronitis, an inflammation of the gum tissue around a partially erupted tooth, often presents with pain, trismus, and lymphadenopathy, requiring timely intervention. [Q0439]
  • Koplik’s spots are a classic sign of measles, aiding in the early and accurate diagnosis of this viral infection. [Q0598]
  • Steven-Johnson syndrome does not involve alveolar bone resorption, distinguishing it from periodontal diseases and infections that do. [Q0691]
  • Food poisoning and diarrhea are commonly caused by bacteria, viruses, parasites, and toxins, requiring appropriate identification and management to prevent outbreaks. [Q3742]
  • Common causes of food poisoning include Salmonella, E. coli, and Norovirus, which are significant pathogens requiring targeted public health measures. [Q3743]
  • Listerine and Triclosan are phenols and more effective against gram-negative bacteria, making them useful in managing bacterial load in the oral cavity. [Q4258]
  • Candidiasis typically presents as white patches on the oral mucosa, which can be diagnostic of this fungal infection. [Q4297]
  • Candidiasis lesions, when scraped off, leave an erythematous area, aiding in the clinical diagnosis of this condition. [Q4298]
  • Not only primary lesions can be infectious; secondary lesions can also be infectious, emphasizing the need for comprehensive infection control measures. [Q4481]
  • Escherichia coli (E. coli) is the most common cause of urinary tract infections, highlighting the importance of this pathogen in clinical practice. [Q4489]
  • Primary herpes simplex infection is rare in adults and more common in children, which helps guide diagnosis and management strategies. [Q4665]

Metabolic and Endocrine Disorders

  • Hyperparathyroidism can lead to increased bone resorption and radiolucent lesions in the jaw, necessitating thorough endocrine evaluation. [Q0050]
  • Hyperthyroidism does not typically feature an absent lamina dura on radiographs, distinguishing it from other conditions like hyperparathyroidism. [Q0249]
  • Brown skin pigmentation is not a characteristic of hyperparathyroidism but is seen in conditions like Addison’s disease and Peutz-Jeghers syndrome, aiding differential diagnosis. [Q0290]
  • In the early stages, Paget’s disease shows a “ground glass” appearance in the jaws, which is a distinctive radiographic feature aiding diagnosis. [Q0359]
  • Paget’s disease typically shows normal calcium and phosphate levels but elevated alkaline phosphatase, which are important laboratory findings for diagnosis. [Q0498]
  • Addison’s disease is characterized by hyperpigmentation of the skin and mucous membranes, which are key diagnostic features. [Q0604]
  • The mosaic pattern of bone seen under the microscope is a hallmark of Paget’s disease, reflecting disorganized bone remodeling. [Q0627]
  • In Paget’s disease, the maxilla is more commonly affected than the mandible, and the vault of the skull is more affected than the facial skeleton, which are key diagnostic features. [Q4096]
  • Loss of lamina dura and jaw radiolucencies are associated with hyperparathyroidism, aiding in the radiographic diagnosis of this endocrine disorder. [Q4466]
  • Endogenous overproduction of ACTH leads to Cushing’s syndrome, necessitating careful endocrine evaluation and management. [Q4552]
  • The pituitary gland secretes hormones that regulate other glands, playing a crucial role in the endocrine system’s overall function. [Q4622]
  • Antacid medication is essential to manage acid reflux in hiatus hernia, preventing further tooth surface loss and improving patient outcomes. [Q6107]

Neurological Disorders

  • The glossopharyngeal nerve is primarily responsible for the gag reflex, which is an important consideration in dental procedures. [Q0457]
  • Increased intracranial pressure often leads to changes in blood pressure, requiring careful monitoring in patients with maxillofacial fractures. [Q0568]
  • Temporal arteritis is characterized by pain, enlarged temporal artery, and visual disturbances, requiring prompt diagnosis and treatment to prevent complications. [Q3097]
  • Drooling and dysphagia can be symptoms of ALS, necessitating a thorough neurological evaluation for accurate diagnosis. [Q4551]
  • Temporal arteritis often causes temple pain and fatigue, which are key symptoms for clinical diagnosis and management. [Q4553]

Nutritional Disorders

  • Vitamin B deficiency, particularly riboflavin deficiency, can cause bilateral cheilosis, highlighting the importance of nutritional assessment in patients with these symptoms. [Q0906]
  • Iron deficiency can cause pigmentation changes, including around the mouth, necessitating thorough nutritional evaluation and management. [Q3087]
  • Recurrent candidiasis and aphthous stomatitis can be associated with folate deficiency, emphasizing the importance of addressing nutritional deficiencies in these conditions. [Q4726]